Atherosclerotic lesion development in a novel ovary-intact mouse model of perimenopause.

The VCD Mouse Model of Menopause and Perimenopause for the Study of Sex Differences in Cardiovascular Disease and the Metabolic Syndrome.

In females, menopause, the cessation of menstrual cycling, is associated with an increase in risk for several diseases such as cardiovascular disease, osteoporosis, diabetes, the metabolic syndrome, and ovarian cancer. The majority of women enter menopause via a gradual reduction of ovarian function over several years (perimenopause) and retain residual ovarian tissue. The VCD mouse model of me...

ANG II-induced hypertension in the VCD mouse model of menopause is prevented by estrogen replacement during perimenopause.

Premenopausal females are resistant to the development of hypertension, and this protection is lost after the onset of menopause, resulting in a sharp increase in disease onset and severity. However, it is unknown how a fluctuating ovarian hormone environment during the transition from perimenopause to menopause impacts the onset of hypertension, and whether interventions during perimenopause p...

Steroid Production and Follicular Development of Neonatal Mouse Ovary during In Vitro Culture

I-19: The Selective Vitamin D Receptor Agonist Elocalcitol Reduces Development of Endometriosis and Formation of Peritoneal Adhesion in A Mouse Model

Background: Endometriosis is a chronic disorder characterized by the presence of endometrial tissue outside the uterus. Endometrial cells from retrograde menstruation implant on peritoneal surfaces and elicit an inflammatory response, associated with angiogenesis, fibrosis, neuronal infiltration, and anatomical distortion. Affecting an estimated 176 million women worldwide, the condition is sti...

Identification of Spata-19 New Variant with Expression beyond Meiotic Phase of Mouse Testis Development

Background: The study of specific genes expressed in the testis is important to understanding testis development and function. Spermatogenesis is an attractive model for the study of gene expression during germ cell differentiation. Spermatogenesis associated-19 (Spata-19) is a recently-identified important spermatogenesis-related gene specifically expressed in testis. Its protein product is in...